Seroatlas · Human Serome Atlas

ABHD4

(Lyso)-N-acylphosphatidylethanolamine lipase

Also known as: ABHD4_HUMAN, FLJ12816

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TB40
Gene: ABHD4
Ensembl: ENSG00000100439
Chromosome: 14
Canonical length: 342 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable lysophosphatidic acid acyltransferase activity and lysophospholipase activity. Predicted to be involved in N-acylphosphatidylethanolamine metabolic process; lipid homeostasis; and phosphatidic acid biosynthetic process. Predicted to act upstream of or within N-acylethanolamine metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in lipid droplet and mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q8TB40|ABHD4
     1  MADDLEQQSQ GWLSSWLPTW RPTSMSQLKN VEARILQCLQ NKFLARYVSL PNQNKIWTVT
    61  VSPEQNDRTP LVMVHGFGGG VGLWILNMDS LSARRTLHTF DLLGFGRSSR PAFPRDPEGA
   121  EDEFVTSIET WRETMGIPSM ILLGHSLGGF LATSYSIKYP DRVKHLILVD PWGFPLRPTN
   181  PSEIRAPPAW VKAVASVLGR SNPLAVLRVA GPWGPGLVQR FRPDFKRKFA DFFEDDTISE
   241  YIYHCNAQNP SGETAFKAMM ESFGWARRPM LERIHLIRKD VPITMIYGSD TWIDTSTGKK
   301  VKMQRPDSYV RDMEIKGASH HVYADQPHIF NAVVEEICDS VD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

esophagus: 41 nTPM
testis: 39 nTPM
blood vessel: 38 nTPM
seminal vesicle: 35 nTPM
choroid plexus: 32 nTPM
adrenal gland: 30 nTPM

Single-cell type

platelets: 126 nCPM
megakaryocyte progenitors: 52 nCPM
esophageal apical cells: 43 nCPM
syncytiotrophoblasts: 41 nCPM
sertoli cells: 31 nCPM
esophageal suprabasal cells: 27 nCPM

Immune cell

basophil: 39 nTPM
neutrophil: 28 nTPM
eosinophil: 11 nTPM
gdT-cell: 9 nTPM
NK-cell: 8.1 nTPM
MAIT T-cell: 7.5 nTPM

Brain region

medulla oblongata: 38 nTPM
choroid plexus: 37 nTPM
white matter: 32 nTPM
midbrain: 31 nTPM
hypothalamus: 31 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD4 as an antibody target. Whether an autoantibody or antibody against ABHD4 could matter depends on whether native ABHD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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