Seroatlas · Human Serome Atlas

ABHD3

Phospholipase ABHD3

Also known as: ABHD3_HUMAN, LABH3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WU67
Gene: ABHD3
Ensembl: ENSG00000158201
Chromosome: 18
Canonical length: 409 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>Q8WU67|ABHD3
     1  MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS SIAKKPQLVT
    61  GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT SKPPVQYRNE LIKTADGGQI
   121  SLDWFDNDNS TCYMDASTRP TILLLPGLTG TSKESYILHM IHLSEELGYR CVVFNNRGVA
   181  GENLLTPRTY CCANTEDLET VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM
   241  AAATFSVGWN TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS
   301  IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP SHAIPIETAK
   361  QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA MVEHGHELS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

rectum: 62 nTPM
colon: 60 nTPM
small intestine: 53 nTPM
duodenum: 42 nTPM
liver: 37 nTPM
stomach: 34 nTPM

Single-cell type

myonuclei: 655 nCPM
epididymal clear cells: 519 nCPM
endometrial luminal cells: 514 nCPM
neutrophils: 488 nCPM
pancreatic duct cells: 464 nCPM
esophageal apical cells: 462 nCPM

Immune cell

basophil: 90 nTPM
neutrophil: 82 nTPM
non-classical monocyte: 62 nTPM
T-reg: 45 nTPM
intermediate monocyte: 44 nTPM
eosinophil: 29 nTPM

Brain region

choroid plexus: 36 nTPM
cerebellum: 22 nTPM
thalamus: 22 nTPM
pons: 22 nTPM
midbrain: 21 nTPM
white matter: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD3 as an antibody target. Whether an autoantibody or antibody against ABHD3 could matter depends on whether native ABHD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD3 is annotated at the cell surface, where native ABHD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ABHD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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