Seroatlas · Human Serome Atlas

ABHD2

Monoacylglycerol lipase ABHD2

Also known as: ABHD2_HUMAN, LABH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08910
Gene
ABHD2
Ensembl
ENSG00000140526
Chromosome
15
Canonical length
425 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol,Connecting piece,Flagellar centriole

OverviewNCBI Gene

This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>P08910|ABHD2
     1  MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG LSRFLLKSCP
    61  LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF ITMSDGATST FDLFEPLAEH
   121  CVGDDITMVI CPGIANHSEK QYIRTFVDYA QKNGYRCAVL NHLGALPNIE LTSPRMFTYG
   181  CTWEFGAMVN YIKKTYPLTQ LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL
   241  RAQETFMQWD QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL
   301  MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE SLLTIPKSLS
   361  EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY ANAICQWERN KLQCSDTEQV
   421  EADLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
129 nTPM

Expression across tissuesHPA

Tissue

  • liver: 129 nTPM
  • stomach: 69 nTPM
  • choroid plexus: 65 nTPM
  • pancreas: 55 nTPM
  • epididymis: 53 nTPM
  • testis: 49 nTPM

Single-cell type

  • neutrophils: 908 nCPM
  • late spermatids: 806 nCPM
  • hepatocytes: 692 nCPM
  • foveolar cells: 670 nCPM
  • oligodendrocyte progenitor cells: 642 nCPM
  • epididymal principal cells: 464 nCPM

Immune cell

  • eosinophil: 70 nTPM
  • neutrophil: 53 nTPM
  • non-classical monocyte: 18 nTPM
  • classical monocyte: 14 nTPM
  • intermediate monocyte: 11 nTPM
  • NK-cell: 11 nTPM

Brain region

  • choroid plexus: 328 nTPM
  • cerebellum: 134 nTPM
  • midbrain: 123 nTPM
  • hippocampal formation: 112 nTPM
  • cerebral cortex: 107 nTPM
  • thalamus: 105 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.68
gnomAD missense Z
2.23
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD2 as an antibody target. Whether an autoantibody or antibody against ABHD2 could matter depends on whether native ABHD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD2 is annotated at the cell surface, where native ABHD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ABHD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABHD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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