Seroatlas · Human Serome Atlas

ABHD18

Protein ABHD18

Also known as: ABD18_HUMAN, C4orf29, FLJ21106

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0P651
Gene: ABHD18
Ensembl: ENSG00000164074
Chromosome: 4
Canonical length: 414 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>Q0P651|ABHD18
     1  MGVSKLDILY RRLLLTKLFI RGWGRPEDLK RLFEFRKMIG NRERCQNLVS SDYPVHIDKI
    61  EEQSDCKILD GHFVSPMAHY VPDIMPIESV IARFQFIVPK EWNSKYRPVC IHLAGTGDHH
   121  YWRRRTLMAR PMIKEARMAS LLLENPYYGC RKPKDQVRSS LKNVSDLFVM GGALVLESAA
   181  LLHWLEREGY GPLGMTGISM GGHMASLAVS NWPKPMPLIP CLSWSTASGV FTTTDSFKMG
   241  QEFVKHFTSS ADKLTNLNLV SRTLNLDISN QVVSQKPADC HNSSKTSVSA TSEGLLLQDT
   301  SKMKRFNQTL STNKSGYTSR NPQSYHLLSK EQSRNSLRKE SLIFMKGVMD ECTHVANFSV
   361  PVDPSLIIVV QAKEDAYIPR TGVRSLQEIW PGCEIRYLEG GHISAYLFKQ GLFR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 13 nTPM
tongue: 11 nTPM
skeletal muscle: 10 nTPM
liver: 7.7 nTPM
pancreas: 7.1 nTPM
duodenum: 6.6 nTPM

Single-cell type

myonuclei: 261 nCPM
lactotrophs: 198 nCPM
somatotrophs: 194 nCPM
retinal ganglion cells: 193 nCPM
gonadotrophs: 167 nCPM
cardiomyocytes: 161 nCPM

Immune cell

basophil: 14 nTPM
neutrophil: 12 nTPM
eosinophil: 8.7 nTPM
naive B-cell: 7.8 nTPM
plasmacytoid DC: 7.8 nTPM
naive CD4 T-cell: 7.2 nTPM

Brain region

cerebellum: 20 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 13 nTPM
white matter: 13 nTPM
pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Alpha/Beta hydrolase fold
Alpha/beta hydrolase domain-containing protein 18
Alpha/beta hydrolase domain containing 18

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD18 as an antibody target. Whether an autoantibody or antibody against ABHD18 could matter depends on whether native ABHD18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD18 is annotated as secreted, so native ABHD18 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ABHD18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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