Seroatlas · Human Serome Atlas

ABHD17C

Alpha/beta hydrolase domain-containing protein 17C

Also known as: AB17C_HUMAN, FAM108C1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PCB6
Gene: ABHD17C
Ensembl: ENSG00000136379
Chromosome: 15
Canonical length: 329 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Predicted to be located in dendritic spine; postsynaptic density membrane; and recycling endosome membrane. Predicted to be active in endosome membrane; glutamatergic synapse; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q6PCB6|ABHD17C
     1  MPEPGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVLAPEQR GAGASAPAPA
    61  QATAAAAAAQ PAPQQPEEGA GAGPGACSLH LSERADWQYS QRELDAVEVF FSRTARDNRL
   121  GCMFVRCAPS SRYTLLFSHG NAVDLGQMCS FYIGLGSRIN CNIFSYDYSG YGVSSGKPSE
   181  KNLYADIDAA WQALRTRYGV SPENIILYGQ SIGTVPTVDL ASRYECAAVI LHSPLMSGLR
   241  VAFPDTRKTY CFDAFPSIDK ISKVTSPVLV IHGTEDEVID FSHGLAMYER CPRAVEPLWV
   301  EGAGHNDIEL YAQYLERLKQ FISHELPNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD17C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

colon: 61 nTPM
rectum: 53 nTPM
esophagus: 45 nTPM
stomach: 34 nTPM
small intestine: 29 nTPM
urinary bladder: 27 nTPM

Single-cell type

esophageal apical cells: 338 nCPM
foveolar cells: 245 nCPM
colonocytes: 235 nCPM
goblet cells: 223 nCPM
respiratory basal cells: 192 nCPM
ocular epithelial cells: 156 nCPM

Immune cell

gdT-cell: 0.7 nTPM
memory CD8 T-cell: 0.7 nTPM
MAIT T-cell: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM
memory B-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM

Brain region

hippocampal formation: 22 nTPM
hypothalamus: 20 nTPM
basal ganglia: 19 nTPM
amygdala: 19 nTPM
cerebral cortex: 19 nTPM
spinal cord: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.96
gnomAD missense Z: 3.14
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

palmitoyl-(protein) hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD17C as an antibody target. Whether an autoantibody or antibody against ABHD17C could matter depends on whether native ABHD17C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD17C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD17C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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