Seroatlas · Human Serome Atlas

ABHD17B

Alpha/beta hydrolase domain-containing protein 17B

Also known as: AB17B_HUMAN, C9orf77, CGI-67, FAM108B1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VST6
Gene: ABHD17B
Ensembl: ENSG00000107362
Chromosome: 9
Canonical length: 288 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q5VST6|ABHD17B
     1  MNNLSFSELC CLFCCPPCPG KIASKLAFLP PDPTYTLMCD ESGSRWTLHL SERADWQYSS
    61  REKDAIECFM TRTSKGNRIA CMFVRCSPNA KYTLLFSHGN AVDLGQMSSF YIGLGSRINC
   121  NIFSYDYSGY GASSGKPTEK NLYADIEAAW LALRTRYGIR PENVIIYGQS IGTVPSVDLA
   181  ARYESAAVIL HSPLTSGMRV AFPDTKKTYC FDAFPNIDKI SKITSPVLII HGTEDEVIDF
   241  SHGLALFERC QRPVEPLWVE GAGHNDVELY GQYLERLKQF VSQELVNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD17B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

thymus: 31 nTPM
spinal cord: 26 nTPM
retina: 24 nTPM
hippocampal formation: 19 nTPM
bone marrow: 18 nTPM
cerebral cortex: 17 nTPM

Single-cell type

rod photoreceptor cells: 435 nCPM
oligodendrocytes: 208 nCPM
urothelial cells: 198 nCPM
lymphatic endothelial cells: 163 nCPM
colonocytes: 157 nCPM
innate lymphoid cells: 155 nCPM

Immune cell

naive B-cell: 4.2 nTPM
basophil: 3.6 nTPM
NK-cell: 3.3 nTPM
plasmacytoid DC: 2.6 nTPM
T-reg: 2.5 nTPM
myeloid DC: 2.2 nTPM

Brain region

white matter: 87 nTPM
basal ganglia: 54 nTPM
cerebral cortex: 45 nTPM
midbrain: 43 nTPM
spinal cord: 42 nTPM
medulla oblongata: 42 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ABHD17B.

Disease | ImmuneIEDB

Conditions an epitope on ABHD17B was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.25
gnomAD missense Z: 2.62
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

palmitoyl-(protein) hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD17B as an antibody target. Whether an autoantibody or antibody against ABHD17B could matter depends on whether native ABHD17B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD17B is annotated at the cell surface, where native ABHD17B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ABHD17B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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