Seroatlas · Human Serome Atlas

ABHD17A

Alpha/beta hydrolase domain-containing protein 17A

Also known as: AB17A_HUMAN, C19orf27, FAM108A1, MGC5244

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GS6
Gene: ABHD17A
Ensembl: ENSG00000129968
Chromosome: 19
Canonical length: 310 aa
Protein class: Enzymes, Predicted intracellular proteins, Transporters
Subcellular location: Nuclear speckles,Vesicles

OverviewNCBI Gene

Enables palmitoyl-(protein) hydrolase activity. Involved in negative regulation of NLRP3 inflammasome complex assembly; protein depalmitoylation; and protein localization to membrane. Located in endosome membrane; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q96GS6|ABHD17A
     1  MNGLSLSELC CLFCCPPCPG RIAAKLAFLP PEATYSLVPE PEPGPGGAGA APLGTLRASS
    61  GAPGRWKLHL TERADFQYSQ RELDTIEVFP TKSARGNRVS CMYVRCVPGA RYTVLFSHGN
   121  AVDLGQMSSF YIGLGSRLHC NIFSYDYSGY GASSGRPSER NLYADIDAAW QALRTRYGIS
   181  PDSIILYGQS IGTVPTVDLA SRYECAAVVL HSPLTSGMRV AFPDTKKTYC FDAFPNIEKV
   241  SKITSPVLII HGTEDEVIDF SHGLALYERC PKAVEPLWVE GAGHNDIELY SQYLERLRRF
   301  ISQELPSQRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD17A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 203 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 203 nTPM
spinal cord: 168 nTPM
cerebral cortex: 161 nTPM
amygdala: 160 nTPM
basal ganglia: 130 nTPM
midbrain: 120 nTPM

Single-cell type

platelets: 176 nCPM
megakaryocytes: 161 nCPM
nk-cells: 151 nCPM
cytotrophoblasts: 72 nCPM
hofbauer cells: 68 nCPM
t-cells: 67 nCPM

Immune cell

gdT-cell: 5.2 nTPM
eosinophil: 4.3 nTPM
MAIT T-cell: 3.8 nTPM
memory B-cell: 3.7 nTPM
memory CD8 T-cell: 3.5 nTPM
NK-cell: 3.2 nTPM

Brain region

cerebral cortex: 173 nTPM
hippocampal formation: 168 nTPM
medulla oblongata: 161 nTPM
pons: 149 nTPM
amygdala: 148 nTPM
thalamus: 147 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0.02
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

palmitoyl-(protein) hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD17A as an antibody target. Whether an autoantibody or antibody against ABHD17A could matter depends on whether native ABHD17A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD17A is annotated at the cell surface, where native ABHD17A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ABHD17A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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