Seroatlas · Human Serome Atlas

ABHD16B

Also known as: ABHGB_HUMAN, C20orf135, dJ591C20.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3Z7
Gene: ABHD16B
Ensembl: ENSG00000183260
Chromosome: 20
Canonical length: 469 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable monoacylglycerol lipase activity and phospholipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q9H3Z7|ABHD16B
     1  MCVICFVKAL VRVFKIYLTA SYTYPFRGWP VAFRWDDVRA VGRSSSHRAL TCAAAAAGVW
    61  LLRDETLGGD ALGRPPRGAR SQAQCLLQQL RELPGQLASY ALAHSLGRWL VYPGSVSLMT
   121  RALLPLLQQG QERLVERYHG RRAKLVACDG NEIDTMFMDR RQHPGSHVHG PRLVICCEGN
   181  AGFYEMGCLS APLEAGYSVL GWNHPGFGSS TGVPFPQHDA NAMDVVVEYA LHRLHFPPAH
   241  LVVYGWSVGG FTATWATMTY PELGALVLDA TFDDLVPLAL KVMPHSWKGL VVRTVREHFN
   301  LNVAEQLCCY PGPVLLLRRT QDDVVSTSGR LRPLSPGDVE GNRGNELLLR LLEHRYPVVM
   361  AREGRAVVTR WLRAGSLAQE AAFYARYRVD EDWCLALLRS YRARCEEELE GEEALGPHGP
   421  AFPWLVGQGL SSRRRRRLAL FLARKHLKNV EATHFSPLEP EEFQLPWRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD16B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
spleen: 3.4 nTPM
appendix: 2.4 nTPM
stomach: 2.1 nTPM
adipose tissue: 2 nTPM
pancreas: 2 nTPM

Single-cell type

late spermatids: 432 nCPM
early spermatids: 158 nCPM
late primary spermatocytes: 28 nCPM
epicardial cells: 2.3 nCPM
cardiomyocytes: 2.2 nCPM
peritubular myoid cells: 2.2 nCPM

Immune cell

eosinophil: 2.7 nTPM
T-reg: 0.8 nTPM
total PBMC: 0.8 nTPM
classical monocyte: 0.7 nTPM
gdT-cell: 0.7 nTPM
myeloid DC: 0.6 nTPM

Brain region

thalamus: 17 nTPM
cerebral cortex: 12 nTPM
pons: 11 nTPM
midbrain: 11 nTPM
amygdala: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: 0.05
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD16B as an antibody target. Whether an autoantibody or antibody against ABHD16B could matter depends on whether native ABHD16B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD16B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD16B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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