Seroatlas · Human Serome Atlas

ABHD14A

Protein ABHD14A

Also known as: ABHEA_HUMAN, DKFZP564O243, DORZ1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUJ0
Gene: ABHD14A
Ensembl: ENSG00000248487
Chromosome: 3
Canonical length: 271 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable hydrolase activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q9BUJ0|ABHD14A
     1  MVGALCGCWF RLGGARPLIP LGPTVVQTSM SRSQVALLGL SLLLMLLLYV GLPGPPEQTS
    61  CLWGDPNVTV LAGLTPGNSP IFYREVLPLN QAHRVEVVLL HGKAFNSHTW EQLGTLQLLS
   121  QRGYRAVALD LPGFGNSAPS KEASTEAGRA ALLERALRDL EVQNAVLVSP SLSGHYALPF
   181  LMRGHHQLHG FVPIAPTSTQ NYTQEQFWAV KTPTLILYGE LDHILARESL RQLRHLPNHS
   241  VVKLRNAGHA CYLHKPQDFH LVLLAFLDHL P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD14A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 100 nTPM
cerebellum: 92 nTPM
cerebral cortex: 71 nTPM
hypothalamus: 65 nTPM
amygdala: 54 nTPM
basal ganglia: 54 nTPM

Single-cell type

cardiomyocytes: 579 nCPM
other brain neurons: 61 nCPM
adipocytes: 55 nCPM
brain excitatory neurons: 46 nCPM
rod photoreceptor cells: 42 nCPM
brain inhibitory neurons: 40 nCPM

Immune cell

MAIT T-cell: 96 nTPM
gdT-cell: 94 nTPM
T-reg: 88 nTPM
memory CD8 T-cell: 83 nTPM
memory CD4 T-cell: 81 nTPM
naive CD8 T-cell: 79 nTPM

Brain region

cerebellum: 75 nTPM
hypothalamus: 69 nTPM
choroid plexus: 66 nTPM
cerebral cortex: 65 nTPM
basal ganglia: 59 nTPM
hippocampal formation: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD14A as an antibody target. Whether an autoantibody or antibody against ABHD14A could matter depends on whether native ABHD14A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD14A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD14A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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