Seroatlas · Human Serome Atlas

ABHD13

Protein ABHD13

Also known as: ABHDD_HUMAN, bA153I24.2, BEM46L1, C13orf6, FLJ14906

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L211
Gene: ABHD13
Ensembl: ENSG00000139826
Chromosome: 13
Canonical length: 337 aa
Protein class: Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable palmitoyl-(protein) hydrolase activity. Predicted to be involved in protein depalmitoylation. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q7L211|ABHD13
     1  MEKSWMLWNF VERWLIALAS WSWALCRISL LPLIVTFHLY GGIILLLLIF ISIAGILYKF
    61  QDVLLYFPEQ PSSSRLYVPM PTGIPHENIF IRTKDGIRLN LILIRYTGDN SPYSPTIIYF
   121  HGNAGNIGHR LPNALLMLVN LKVNLLLVDY RGYGKSEGEA SEEGLYLDSE AVLDYVMTRP
   181  DLDKTKIFLF GRSLGGAVAI HLASENSHRI SAIMVENTFL SIPHMASTLF SFFPMRYLPL
   241  WCYKNKFLSY RKISQCRMPS LFISGLSDQL IPPVMMKQLY ELSPSRTKRL AIFPDGTHND
   301  TWQCQGYFTA LEQFIKEVVK SHSPEEMAKT SSNVTII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 15 nTPM
liver: 9.8 nTPM
epididymis: 9.6 nTPM
thymus: 8.7 nTPM
placenta: 7.9 nTPM
lymph node: 7.7 nTPM

Single-cell type

neutrophils: 80 nCPM
choroid plexus epithelial cells: 67 nCPM
neutrophil progenitors: 67 nCPM
esophageal apical cells: 49 nCPM
suprabasal keratinocytes: 45 nCPM
late primary spermatocytes: 44 nCPM

Immune cell

eosinophil: 16 nTPM
NK-cell: 9.6 nTPM
neutrophil: 9 nTPM
MAIT T-cell: 8.8 nTPM
total PBMC: 8.6 nTPM
T-reg: 8.4 nTPM

Brain region

choroid plexus: 15 nTPM
cerebellum: 13 nTPM
cerebral cortex: 11 nTPM
hippocampal formation: 8.8 nTPM
white matter: 8.3 nTPM
basal ganglia: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.89
gnomAD missense Z: 1.47
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

palmitoyl-(protein) hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD13 as an antibody target. Whether an autoantibody or antibody against ABHD13 could matter depends on whether native ABHD13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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