Seroatlas · Human Serome Atlas

ABHD12B

Protein ABHD12B

Also known as: AB12B_HUMAN, BEM46L3, C14orf29

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5M8
Gene: ABHD12B
Ensembl: ENSG00000131969
Chromosome: 14
Canonical length: 362 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable lysophospholipase activity and monoacylglycerol lipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>Q7Z5M8|ABHD12B
     1  MDAQDCQAAA SPEPPGPPAR SCVAAWWDMV DRNLRYFPHS CSMLGRKIAA LYDSFTSKSL
    61  KEHVFLPLID MLIYFNFFKA PFLVDLKKPE LKIPHTVNFY LRVEPGVMLG IWHTVPSCRG
   121  EDAKGKDCCW YEAALRDGNP IIVYLHGSAE HRAASHRLKL VKVLSDGGFH VLSVDYRGFG
   181  DSTGKPTEEG LTTDAICVYE WTKARSGITP VCLWGHSLGT GVATNAAKVL EEKGCPVDAI
   241  VLEAPFTNMW VASINYPLLK IYRNIPGFLR TLMDALRKDK IIFPNDENVK FLSSPLLILH
   301  GEDDRTVPLE YGKKLYEIAR NAYRNKERVK MVIFPPGFQH NLLCKSPTLL ITVRDFLSKQ
   361  WS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD12B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

retina: 13 nTPM
skin: 9.8 nTPM
basal ganglia: 6.3 nTPM
cerebral cortex: 2.3 nTPM
bone marrow: 1.3 nTPM
breast: 1.1 nTPM

Single-cell type

müller glia: 234 nCPM
adipocytes: 64 nCPM
epicardial cells: 64 nCPM
rod photoreceptor cells: 53 nCPM
oocytes: 41 nCPM
respiratory ciliated cells: 31 nCPM

Immune cell

neutrophil: 2.2 nTPM
eosinophil: 1 nTPM
basophil: 0.3 nTPM
classical monocyte: 0.3 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

thalamus: 20 nTPM
basal ganglia: 20 nTPM
midbrain: 17 nTPM
amygdala: 12 nTPM
cerebral cortex: 11 nTPM
hypothalamus: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Hydrolase

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD12B as an antibody target. Whether an autoantibody or antibody against ABHD12B could matter depends on whether native ABHD12B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD12B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD12B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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