Seroatlas · Human Serome Atlas

ABHD1

Protein ABHD1

Also known as: ABHD1_HUMAN, FLJ36128, LABH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SE0
Gene: ABHD1
Ensembl: ENSG00000143994
Chromosome: 2
Canonical length: 405 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the AB hydrolase superfamily and encodes a protein with an alpha/beta hydrolase fold. This domain is common to a number of hydrolytic enzymes of widely differing phylogenetic origins and catalytic functions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

405 residues, UniProt reviewed canonical sequence.

>Q96SE0|ABHD1
     1  MLSSFLSPQN GTWADTFSLL LALAVALYLG YYWACVLQRP RLVAGPQFLA FLEPHCSITT
    61  ETFYPTLWCF EGRLQSIFQV LLQSQPLVLY QSDILQTPDG GQLLLDWAKQ PDSSQDPDPT
   121  TQPIVLLLPG ITGSSQETYV LHLVNQALRD GYQAVVFNNR GCRGEELRTH RAFCASNTED
   181  LETVVNHIKH RYPQAPLLAV GISFGGILVL NHLAQARQAA GLVAALTLSA CWDSFETTRS
   241  LETPLNSLLF NQPLTAGLCQ LVERNRKVIE KVVDIDFVLQ ARTIRQFDER YTSVAFGYQD
   301  CVTYYKAASP RTKIDAIRIP VLYLSAADDP FSPVCALPIQ AAQHSPYVAL LITARGGHIG
   361  FLEGLLPWQH WYMSRLLHQY AKAIFQDPEG LPDLRALLPS EDRNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
liver: 3.1 nTPM
skeletal muscle: 1.8 nTPM
tongue: 1.6 nTPM
salivary gland: 1.4 nTPM
adipose tissue: 1.1 nTPM

Single-cell type

late spermatids: 1,933 nCPM
early spermatids: 300 nCPM
late primary spermatocytes: 223 nCPM
myonuclei: 19 nCPM
cone photoreceptor cells: 10 nCPM
epididymal principal cells: 7.8 nCPM

Immune cell

eosinophil: 0.8 nTPM
gdT-cell: 0.6 nTPM
memory B-cell: 0.5 nTPM
memory CD4 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM

Brain region

cerebellum: 3 nTPM
cerebral cortex: 2.1 nTPM
thalamus: 1.8 nTPM
medulla oblongata: 1.7 nTPM
pons: 1.7 nTPM
spinal cord: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.95
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD1 as an antibody target. Whether an autoantibody or antibody against ABHD1 could matter depends on whether native ABHD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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