Seroatlas · Human Serome Atlas

AARD

Alanine- and arginine-rich domain-containing protein

Also known as: AARD_HUMAN, C8orf85, LOC441376

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4LEZ3
Gene: AARD
Ensembl: ENSG00000205002
Chromosome: 8
Canonical length: 155 aa
Protein class: Predicted intracellular proteins
Subcellular location: Lipid droplets

OverviewNCBI Gene

Predicted to act upstream of or within response to testosterone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>Q4LEZ3|AARD
     1  MGPGDFRRCR ERISQGLQGL PGRAELWFPP RPACDFFGDG RSTDIQEEAL AASPLLEDLR
    61  RRLTRAFQWA VQRAISRRVQ EAAAAAAARE EQSWTGVEAT LARLRAELVE MHFQNHQLAR
   121  TLLDLNMKVQ QLKKEYELEI TSDSQSPKDD AANPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AARD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
urinary bladder: 7.1 nTPM
stomach: 6.4 nTPM
colon: 5.4 nTPM
breast: 4 nTPM
lung: 2.4 nTPM

Single-cell type

late primary spermatocytes: 126 nCPM
sertoli cells: 78 nCPM
breast secretory cells: 60 nCPM
smooth muscle cells: 40 nCPM
breast myoepithelial cells: 25 nCPM
late spermatids: 25 nCPM

Immune cell

basophil: 1.1 nTPM
neutrophil: 0.7 nTPM
T-reg: 0.6 nTPM
NK-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

white matter: 3.6 nTPM
midbrain: 3.2 nTPM
cerebral cortex: 3 nTPM
medulla oblongata: 3 nTPM
pons: 2.9 nTPM
choroid plexus: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0.33
gnomAD missense Z: -0.31
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

response to testosterone

Protein domainsUniProt · Pfam · InterPro

FAM167 domain-containing protein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AARD as an antibody target. Whether an autoantibody or antibody against AARD could matter depends on whether native AARD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AARD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AARD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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