Seroatlas · Human Serome Atlas

A8MX80

Putative UPF0607 protein ENSP00000383144

Also known as: YM017_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MX80
Gene
A8MX80
Canonical length
341 aa

OverviewNCBI Gene

No narrative summary is available for A8MX80 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>A8MX80|A8MX80
     1  MRLCLIPRNT GTPQRVLPPV VWSTPSRKKP VLSARNSMMF GHLSPMRIPH LRGKFNLQLP
    61  SLDEQVIPAR LPKTEVRAEE PKEATEVKDQ VETQEQEDNK RGPCSNGEAA STSRPLETQG
   121  NLTSSWYNPR PLEGNVHLKS LTEKNQTDKA QVHAVSFYSK GHGVASSHSP AGGILPFGRP
   181  DSLPTVLPAP VPGCSLWPEK AALKVLGKDY LPSSPGLLMV GEDMQPKDPA ALGSSRSSPP
   241  KAAGHRSHKR KLSGPPLQLQ PTPPLQLRWD RDEGPPPAKL PCLSPEALLV GQASQREGHL
   301  QQGNMHKNMR VLSRTSKFRR LRQLLRRRKK RRQGRCGGSR L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against A8MX80 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads A8MX80 as an antibody target. Whether an autoantibody or antibody against A8MX80 could matter depends on whether native A8MX80 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

A8MX80 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label A8MX80 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/A8MX80. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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