Seroatlas · Human Serome Atlas

A8MWP4

Putative uncharacterized protein ENSP00000401716

Also known as: YU008_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MWP4
Gene: A8MWP4
Canonical length: 228 aa

OverviewNCBI Gene

No narrative summary is available for A8MWP4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>A8MWP4|A8MWP4
     1  MQRPHRRQSQ MDAASTRAPP RPSAPQQGRR QPSMPGSAQC HHRPDPHPPA PGKKKSSPVG
    61  RFFPASAMAP PWLPGIVSAA QLKPVLSDLP PHCTRAQCQP LTQRPHSLHL QDSRNASSLP
   121  HKGWRCNFPL QGPAGLTHKS ACVGRMGHCC GSAGNVPELS PRPASPRGQQ VTQDGPLQTP
   181  ELPSECNVGP VMSRQPFPEQ SQQGECAIDP RGPPRLELSW GEDPLSGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against A8MWP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads A8MWP4 as an antibody target. Whether an autoantibody or antibody against A8MWP4 could matter depends on whether native A8MWP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

A8MWP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label A8MWP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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