Seroatlas · Human Serome Atlas

A8MWL6

Putative synaptogyrin-2 like protein

Also known as: SNG2L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MWL6
Gene: A8MWL6
Canonical length: 223 aa

OverviewNCBI Gene

No narrative summary is available for A8MWL6 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>A8MWL6|A8MWL6
     1  MESGAYGVAE AGGSFDLRPF LTQPQVVARA LCLVFALIVF SCIYGEGYSN THKSKQMYCV
    61  FNHNEDACRY GSAIGVLAFL ASAFLVVDAY FPQISNATDR KYLVIGDLLF SALWTFLWFV
   121  GFCFLTNQWA VTDPEDVLVG ADSARAAITF SFFSIFSWGV LASLTYQRYK AGVDDFIQNY
   181  VDPSPDPNTA YASYPGASVD NYQQPPFTQN AETTEGYQPP PVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against A8MWL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.4

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads A8MWL6 as an antibody target. Whether an autoantibody or antibody against A8MWL6 could matter depends on whether native A8MWL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

A8MWL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label A8MWL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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