Seroatlas · Human Serome Atlas

A8MVM7

Putative uncharacterized protein ENSP00000382790

Also known as: YD021_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MVM7
Gene: A8MVM7
Canonical length: 634 aa

OverviewNCBI Gene

No narrative summary is available for A8MVM7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>A8MVM7|A8MVM7
     1  MDKIRHTEAD IFKNGSKRMI ATVPLRHSIR DRKPSLHFLH SLASSSSLIY RNALLHKSYK
    61  LHLQKNKSQK EKHRHSKMKI AYKDTPRNRL SRNAKKCLED NKLVPISEVS LDPIISSNPL
   121  LRWWATSASN DSLLEELNNR FEQITNAWVQ VSGDEAENCI HKKREHIEND HFKVASPLET
   181  CLLELEVSPV KMLFQKKYDL NELCTWFMQT TETQSLSLVR KANARNPLEV INTRGIKLGT
   241  KYSDFNASPF RKHFKKFALS SPSKSAEKLH ILHKVANSPL LNVKSNLAIA RLKRTEFKRL
   301  HHERWKREGK LHNHGTVDWN SKRRNLRFFC QNQFLNKTEG ETNADIPLQG KSIVDNQCVL
   361  PPEIRGDLQQ RVVMPDFKIH ASFENKFKSE AKENGTNCSQ KDFQKGPRLE NVCPNSWRSK
   421  TLKDCRIFLR KLNCLEHRNT FKLNTIIYSP ESTDSGNTHQ THMEESKRFT LRSHSARQNS
   481  FKKQSKEIEN ANTNNPSADE FADHLGNSKL SKCVNFDKNP DSFEVLSNLN KRKRPPWKIT
   541  EMSTKRHKRQ SCNSGQMANY FSKSLVSKIF GQPNFLAPSM KLVKLGAAKC TSALPHLLIC
   601  PGFHTNKNIY SRDIEIIFKI YYFNNVDVIS FCIW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against A8MVM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4553
Domain of unknown function (DUF4553)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads A8MVM7 as an antibody target. Whether an autoantibody or antibody against A8MVM7 could matter depends on whether native A8MVM7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

A8MVM7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label A8MVM7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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