Seroatlas · Human Serome Atlas

A8MVJ9

Putative histone PARylation factor 1-like

Also known as: HPF1L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MVJ9
Gene: A8MVJ9
Canonical length: 347 aa

OverviewNCBI Gene

No narrative summary is available for A8MVJ9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>A8MVJ9|A8MVJ9
     1  MVGGGWKRRP GAGAGPQCEK TVDVKKSKFC EADVSSDLRK EVENHYTLSL PEDFYHFWKF
    61  CEELDSEKPA DPLSASLGLQ LVDPYNILAG KHKMKKKSTV PNFNLHWRFY YDPPEFQTII
   121  IRDKLSATWG ISDRDSPDEL PVYVGINEAK KNCIIVPNGD NVFAAVKLYL MKKLKEVTDK
   181  KKTNLFKNVD EKLTETAREL GYSLEQRTMK MKQRDKKVVT KTFHGTGLVP PVDKNVVGYR
   241  ELPETDADLK RICKTIVEAA SDDERRKAFA PIQEMMTFVQ FANDECDYGM GLELGMDLFC
   301  YGSHYFHKVA GQLLPLAYNL LKRNLFAEIM KDHLANRRKE NIDQFAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against A8MVJ9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Acetylation

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads A8MVJ9 as an antibody target. Whether an autoantibody or antibody against A8MVJ9 could matter depends on whether native A8MVJ9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

A8MVJ9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label A8MVJ9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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