Seroatlas · Human Serome Atlas

A6NNC1

Putative POM121-like protein 1-like

Also known as: P12LL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NNC1
Gene: A6NNC1
Canonical length: 897 aa

OverviewNCBI Gene

No narrative summary is available for A6NNC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

897 residues, UniProt reviewed canonical sequence.

>A6NNC1|A6NNC1
     1  MPEQDKDPRV QENPDDQRTV PEVTGDARSA FWPLRDNGGP SPFVPRPGPL QTDLHAQSSE
    61  IRYNHTSQTS WTSSSTKRNA ISSSYSSTGG LPGLKQRRGP ASSRCQLTLS YSKTVSEDRP
   121  QAVSSGHTRC EKGADTAPGQ TIAPTGGSPR SQDSRPRRRK IPLLPRRRGE PLMLPPPLEL
   181  GYRVTAEDLH LEKETAFQRI NSALHVEDKA IPDCRPSRPS HTLSSLATGA SGGPPVSKAP
   241  TMDAQQDRPK SQDSLGLLAP LASAAEVPST APVSGKKHRP PGPLFSSSDP LPATSYHSRD
   301  TAQVTSLIPA TFTAASRDAG MRRTRSAPAA ATAAPPPSTL NNTSGSLLNA VDGGPSHFLA
   361  SATAAARAQR SEVRYNQRSQ TSRTRSCLKR NASSSSSSHS STEGLQELKR RRGPASSHCQ
   421  LAHSSSNTVS EDGPQAVSSG HRCENKAGTA PGQTLAPRGG SPRSQASRPH INSALYVEDK
   481  AISDCRPSRP SHTLSSLATG ASGGPPVSKA PTMDAQQDRP KSQDCLGLVA PLASAAEVPS
   541  TAPVSGKKHR PPGPLFSSSD PLPATSSHSR DSAQVTSLIP ATFTAASRDA GMRRTRPGTS
   601  APAAAAAALP PSTLNPTSGS LLNAVDGGPS HFLASATAAA RAQRSEVRYN QRSQTSRTRS
   661  CLKRNASSSS HSSTEGLQEL KRRRGPASSH CQLAHSSSNT VSEDGPQAVS SGHRCENKAG
   721  TAPGQTLAPR GGYPRSQASR PRINSALHVE DKAISDCRPS RPSHTLSSLA TGASGGPPVS
   781  KAPTMDAQQD RPKSQDCLGL LAPLASAAEV SSTAPVSGKK HRPPGPLFSS SDPLPATSSH
   841  SGDSAQDTSL IPAPFTPASR DAGIRRMFRV RNCLRGLGLF LLVFSFFFLL TWASFSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against A6NNC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.72

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads A6NNC1 as an antibody target. Whether an autoantibody or antibody against A6NNC1 could matter depends on whether native A6NNC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

A6NNC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label A6NNC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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