Seroatlas · Human Serome Atlas

A6NL46

Putative UPF0607 protein ENSP00000332738

Also known as: YF016_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NL46
Gene
A6NL46
Canonical length
340 aa

OverviewNCBI Gene

No narrative summary is available for A6NL46 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>A6NL46|A6NL46
     1  MRLCLIPWNT TPHRVLPPVV WSAPSRKKPV LSARNSMMFG HLSPVRNPRL RGKFNLQLPS
    61  LDEQVIPTRL PKMEVRAEEP KEATEVKDQV ETQGQEDNKT GPCSNGKAAS TSRPLETQGN
   121  LTSSWYNPRP LEGNVHLKSL TEKNQTDKAQ VHAVSFYSKG HGVTSSHSPA GGILPFGKPD
   181  PLPAVLPAPV PDCSLWPEKA ALKVLGKDHL PSSPGLLMVG EDMQPKDPAA LRSSRSSPPR
   241  AAGHRPRKRK LSGPPLQLQQ TPPLQLRWDR DEGPPPAKLP CLSPEALLVG KASQREGRLQ
   301  QGNMRKNVRV LSRTSKFRRL RQLLRRRKKR WQGRRGGSRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against A6NL46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads A6NL46 as an antibody target. Whether an autoantibody or antibody against A6NL46 could matter depends on whether native A6NL46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

A6NL46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label A6NL46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/A6NL46. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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