Seroatlas · Human Serome Atlas

A3GALT2

Alpha-1,3-galactosyltransferase 2

Also known as: A3GALT2P, A3LT2_HUMAN, IGB3S, IGBS3S

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: U3KPV4
Gene: A3GALT2
Ensembl: ENSG00000184389
Chromosome: 1
Canonical length: 340 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable N-acetyllactosaminide 3-alpha-galactosyltransferase activity and alpha-1,3-galactosyltransferase activity. Predicted to be involved in lipid glycosylation. Predicted to act upstream of or within glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus and vesicle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>U3KPV4|A3GALT2
     1  MALKEGLRAW KRIFWRQILL TLGLLGLFLY GLPKFRHLEA LIPMGVCPSA TMSQLRDNFT
    61  GALRPWARPE VLTCTPWGAP IIWDGSFDPD VAKQEARQQN LTIGLTIFAV GRYLEKYLER
   121  FLETAEQHFM AGQSVMYYVF TELPGAVPRV ALGPGRRLPV ERVARERRWQ DVSMARMRTL
   181  HAALGGLPGR EAHFMFCMDV DQHFSGTFGP EALAESVAQL HSWHYHWPSW LLPFERDAHS
   241  AAAMAWGQGD FYNHAAVFGG SVAALRGLTA HCAGGLDWDR ARGLEARWHD ESHLNKFFWL
   301  HKPAKVLSPE FCWSPDIGPR AEIRRPRLLW APKGYRLLRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against A3GALT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

testis: 0.3 nTPM
bone marrow: 0.2 nTPM
gallbladder: 0.2 nTPM
adipose tissue: 0.1 nTPM
appendix: 0.1 nTPM
cerebellum: 0.1 nTPM

Single-cell type

neutrophils: 49 nCPM
early spermatids: 23 nCPM
early primary spermatocytes: 19 nCPM
differentiating spermatogonia: 14 nCPM
hepatic stellate cells: 13 nCPM
kupffer cells: 12 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 1.2 nTPM
cerebral cortex: 1 nTPM
pons: 0.8 nTPM
amygdala: 0.7 nTPM
basal ganglia: 0.7 nTPM
hypothalamus: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.11
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

glycosyltransferase activity
metal ion binding
N-acetyllactosaminide 3-alpha-galactosyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads A3GALT2 as an antibody target. Whether an autoantibody or antibody against A3GALT2 could matter depends on whether native A3GALT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

A3GALT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label A3GALT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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