HSR domain
PF03172
Definition
The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region) PMID:10212234. The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140) PMID:10049735. This domain is usually found at the amino terminus of proteins that contain a SAND domain [pfam:PF01342].
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...