MutS domain V

Definition

This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with [pfam:PF01624], [pfam:PF05188], [pfam:PF05192] and [pfam:PF05190]. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein PMID:8036718. The aligned region corresponds with domain V of Thermus aquaticus MutS as characterised in PMID:11048710, which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• MSH2
• MSH3
• MSH4
• MSH5
• MSH6