SEZ6/CSMD/C4BPB Neuronal & Immune Regulators
IPR051277
Definition
The SEZ6/CSMD protein family includes members that are involved in various neuronal functions. SEZ6 family proteins are implicated in cell-cell recognition, neuronal membrane signaling, and the development of dendritic arbors, contributing to the establishment of excitatory synaptic connectivity. They may also play a role in specialized endoplasmic reticulum functions within neurons. The CSMD family members are associated with dendrite development and may act as suppressors in certain types of cancer. The C4BPB proteins within this family regulate the classical pathway of complement activation, interact with anticoagulant protein S, and are involved in immune response regulation.
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...