Voltage-dependent calcium channel subunit alpha-2/delta
IPR051173
Definition
The calcium channel subunit alpha-2/delta family comprises proteins that act as regulatory subunits for voltage-dependent calcium channels, influencing calcium current density and activation/inactivation kinetics. These subunits are involved in various calcium-dependent processes, including excitation-contraction coupling and neural depolarization-induced calcium influx. They contain a MIDAS-like motif within the VWFA domain that binds divalent metal cations, essential for trafficking the alpha-1 subunit to the plasma membrane. Some family members may also regulate calcium-activated signaling pathways affecting motor activity and neurotransmitter responses.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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