Metabotropic Glutamate Receptor
IPR050726
Definition
The G-protein coupled receptor 3 family is characterized by its members' ability to act as receptors for glutamate, which upon ligand binding, undergo conformational changes that trigger signaling via guanine nucleotide-binding proteins (G proteins). The signaling pathways modulate the activity of downstream effectors, such as adenylate cyclase, which is commonly inhibited by these receptors. The family plays a crucial role in various neural processes, including synaptic plasticity, neural network activity modulation, and visual signal transduction. Some members are involved in developmental processes like axon outgrowth regulation and eye development. The receptors may also participate in the CNS's central action of glutamate, influencing long-term potentiation and depression.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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