Voltage-dependent calcium channel alpha-1 subunit
IPR050599
Definition
Voltage-dependent L-type calcium channel subunit alpha-1S and related proteins are essential for the mediation of calcium ion entry into excitable cells, triggering a variety of calcium-dependent processes such as muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, division, and cell death. These proteins form high-voltage activated (HVA) channels, which are characterised by their long-lasting calcium currents and sensitivity to specific blockers like dihydropyridines, phenylalkylamines, and benzothiazepines [[cite:PMID:28119464], [cite:PMID:27218670]]. The family includes subunits that give rise to different types of calcium currents, such as L-type, P/Q-type, N-type, and R-type, each with distinct physiological roles and pharmacological profiles [[cite:PMID:25296916], [cite:PMID:24836863], [cite:PMID:30343943]]. The domain architecture of these proteins typically features four internal repeats, each containing six transmembrane segments, with the fourth segment acting as the voltage sensor. This family plays a crucial role in excitation-contraction coupling in muscle and is involved in various signaling pathways critical for cellular function and survival.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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