Type I Cytokine Receptor
IPR050379
Definition
The Type I Cytokine Receptor family is characterized by its role in immune system regulation and hematopoiesis. Members of this family are involved in various signaling pathways, such as JAK/STAT, MAPK, and NOTCH, which lead to diverse biological effects including cell proliferation, differentiation, survival, and inflammation control. They are receptors for a range of cytokines, including interleukins, growth hormone, prolactin, and leptin, mediating responses like growth regulation, appetite control, and immune cell development. The receptors typically feature a WSXWS motif essential for proper folding and transport, and a box 1 motif necessary for interaction with JAK kinases. Some receptors also exist in soluble forms, acting as agonists or modulators of signaling. This family plays a critical role in both central and peripheral functions, affecting processes from bone metabolism to neural development and regeneration.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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