SMCs flexible hinge superfamily

Definition

This entry represents the hinge region superfamily of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that its precise structure is an essential determinant of the specificity of the DNA-protein interaction PMID:12411491. The structure of this hinge region consists of two different α+β subdomains and forms subdomain-swapped dimers.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• SMC1A
• SMC1B
• SMC2
• SMC3
• SMC4
• SMCHD1