Humanin family
IPR028139
Definition
Humanin (HN) and humanin-like proteins are found exclusively in humans. Humanin is a short anti-apoptotic peptide that inhibits the activation of Bax (Bcl-2-associated X protein), which is involved in apoptosis PMID:12732850. Humanin suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults PMID:12009529. Humanin also interacts with the insulin-like growth factor-binding protein-3 (IGFBP-3), which is essential in the regulation of cell survival PMID:14561895. This entry represents the humanin family, and also matches some uncharacterised non-human proteins, mainly from chimpanzee.
13 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...