Cytochrome P450, cholesterol 7-alpha-monooxygenase-type

Definition

This group represents cytochrome P450, CYP7A1 type. Gene cyp7a1 codes for the enzyme cholesterol 7-alpha-monooxygenase, which catalyses a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. This enzyme is important for cholesterol homeostasis PMID:8088795. Some of the enzymes belonging to this group are 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, also involved in bile acid biosynthesis, and prostacyclin synthase, which catalyses the isomerization of prostaglandin H2 to prostacyclin (prostaglandin I2).

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• CYP39A1
• CYP7A1
• CYP7B1
• CYP8B1
• PTGIS