DMAP1-binding domain

Definition

This is a ~120-amino acid protein-protein interaction module that binds DMAP1 (DNA methyltransferase-associated protein 1), a transcriptional co-repressor. It is found at the N terminus of DNMT1 (DNA methyltransferase 1) PMID:10888872 and animal disco-interacting protein 2 (DIP-2), a protein that maintains morphology of mature neurons [[cite:PMID:27908785], [cite:PMID:30396999]]. This domain is also found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTA) and gamma (GNPTG) from animals, which are members of a complex that catalyses the initial step in the formation of the mannose 6-phopsphate targeting signal on newly synthesized lysosomal acid hydrolases. The DMAP1-binding domain mediates the selective binding GlcNAc-1-phosphotranferase to acid hydrolases [[cite:PMID:23733939], [cite:PMID:25505245]]. The DMAP1-binding domain is predicted to adopt a long helix-turn-helix structure that is rich in leucine residues PMID:8940105.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• DIP2A
• DIP2B
• DIP2C
• DNMT1
• GNPTAB
• GNPTG