RecF/RecN/SMC, N-terminal

Definition

This domain is found at the N terminus of structural maintenance of chromosomes (SMC) proteins, which function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair and epigenetic silencing of gene expression PMID:11983169. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics PMID:10429180. This domain is also found in RecF and RecN proteins, which are involved in DNA metabolism and recombination. This domain is also found in urease accessory protein 2 (URE2) which is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle, and Is unrelated to urease function in C.neoformans PMID:23653445.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• SMC1A
• SMC1B
• SMC2
• SMC3
• SMC4
• SMC6