FATC domain
IPR003152
Definition
This entry represents the FATC domain in Serine/threonine-protein kinases and related proteins, including pseudo-kinases such as members of the SAGA and NuA4 complexes. The TOR1 FATC domain, in its oxidised form, consists of an α-helix and a well-structured COOH-terminal disulphide-bonded loop. Reduction of the disulphide bond dramatically increases the flexibility within the COOH-terminal loop region. The reduction may alter the binding behaviour of FATC to its partners PMID:15772072. It has been proposed that the FAT domain could be of importance as a structural scaffold or as a protein-binding domain, or both PMID:7569949. Phosphatidylinositol kinase (PIK)-related kinases participate in meiotic and V(D)J recombination, chromosome maintenance and repair, cell cycle progression, and cell cycle checkpoints, and their dysfunction can result in a range of diseases, including immunodeficiency, neurological disorders and cancer. The catalytic kinase domain is highly homologous to that of phosphatidylinositol 3- and 4-kinases. Nevertheless, members of the PIK-related family appear functionally distinct, as none of them has been shown to phosphorylate lipids, such as phosphatidylinositol; instead, many have Ser/Thr protein kinase activity. The PI-kinase domain of members of the PIK-related family is wedged between the ~550-amino acid-long FAT (FRAP, ATM, TRRAP) domain PMID:7569949 and the ~35-residue C-terminal FATC domain PMID:10782091.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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