Nuclear translocator

Definition

The Ah (dioxin) receptor nuclear translocator protein (Arnt) belongs to the basic helix-loop-helix (bHLH) family of transcription factors and is required for Ah receptor function. The Ah receptor binds, and mediates the carcinogenic effects of a variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Arnt is a structural component of the XRE-binding form of the Ah receptor. These proteins are class VII members of the basic helix-loop-helix (bHLH) family. The bHLH domain may be responsible for interacting with both the XRE and the ligand-binding subunit [[cite:PMID:8065341], [cite:PMID:1317062]].The activated Ah receptor and Arnt protein bind DNA as a heterodimer. Both proteins contain PAS homology regions, which in Drosophila PER and SIM proteins function as dimerisation domains PMID:8065341.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• ARNT
• ARNT2
• BMAL1
• BMAL2
• CLOCK
• EPAS1
• NPAS2