WHEP-TRS domain

Definition

A conserved domain of 46 amino acids, called WHEP-TRS has been shown PMID:1756734 to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in mammalian multifunctional aminoacyl-tRNA synthetase in a region that separates the N-terminal glutamyl-tRNA synthetase domain from the C-terminal prolyl-tRNA synthetase domain, and six copies in the intercatalytic region of the Drosophila enzyme. The domain is found at the N-terminal extremity of the mammalian tryptophanyl-tRNA synthetase and histidyl-tRNA synthetase, and the mammalian, insect, nematode and plant glycyl-tRNA synthetases PMID:8463296. The structure of a human WHEP-TRS domain has been solved and consists of two helices arranged in a helix-turn-helix PMID:11123902. The WHEP-TRS domain may play a role in the association of tRNA-synthetases into multienzyme complexes PMID:9556618.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• EPRS1
• GARS1
• HARS1
• MARS1
• WARS1