Seroatlas · Human Serome Atlas
Human Gene Ontology
4301 GO term categories, each grouping the human proteins that carry it as potential autoantibody targets.
All gene ontology
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- nucleus 5712
- cytosol 5547
- plasma membrane 5373
- cytoplasm 5059
- nucleoplasm 3990
- membrane 3223
- zinc ion binding 2150
- extracellular exosome 2100
- extracellular region 1981
- identical protein binding 1725
- mitochondrion 1647
- extracellular space 1554
- ATP binding 1475
- regulation of transcription by RNA polymerase II 1440
- RNA binding 1377
- DNA-binding transcription factor activity, RNA polymerase II-specific 1232
- metal ion binding 1201
- endoplasmic reticulum membrane 1157
- chromatin 1115
- positive regulation of transcription by RNA polymerase II 1110
- endoplasmic reticulum 1100
- RNA polymerase II cis-regulatory region sequence-specific DNA binding 1078
- Golgi apparatus 1052
- signal transduction 1018
- DNA binding 983
- negative regulation of transcription by RNA polymerase II 924
- nucleolus 900
- protein homodimerization activity 721
- calcium ion binding 712
- perinuclear region of cytoplasm 706
- Golgi membrane 702
- G protein-coupled receptor activity 689
- centrosome 651
- cell surface 649
- protein-containing complex 628
- positive regulation of DNA-templated transcription 582
- glutamatergic synapse 569
- cell differentiation 567
- sequence-specific double-stranded DNA binding 560
- apoptotic process 551
- negative regulation of DNA-templated transcription 522
- regulation of DNA-templated transcription 520
- innate immune response 495
- proteolysis 495
- mitochondrial inner membrane 490
- cell adhesion 484
- positive regulation of cell population proliferation 477
- immune response 475
- DNA-binding transcription factor activity 474
- negative regulation of apoptotic process 472
- synapse 471
- protein kinase binding 468
- spermatogenesis 466
- G protein-coupled receptor signaling pathway 459
- chromatin binding 456
- mitochondrial matrix 444
- DNA-binding transcription activator activity, RNA polymerase II-specific 438
- dendrite 435
- adaptive immune response 431
- olfactory receptor activity 431
- nuclear speck 430
- intracellular signal transduction 426
- inflammatory response 425
- positive regulation of gene expression 420
- extracellular matrix 418
- focal adhesion 417
- protein ubiquitination 399
- ATP hydrolysis activity 398
- nervous system development 397
- apical plasma membrane 391
- lysosomal membrane 389
- negative regulation of cell population proliferation 383
- external side of plasma membrane 382
- GTP binding 380
- protein transport 377
- cytoskeleton 375
- cilium 372
- protein serine/threonine kinase activity 370
- enzyme binding 367
- ubiquitin protein ligase activity 366
- nuclear body 365
- protein serine kinase activity 362
- cell division 353
- signaling receptor binding 350
- axon 346
- neuronal cell body 338
- ciliary basal body 336
- protein heterodimerization activity 335
- GTPase activity 332
- RNA polymerase II transcription regulatory region sequence-specific DNA binding 323
- protein-containing complex binding 322
- endoplasmic reticulum lumen 316
- proteasome-mediated ubiquitin-dependent protein catabolic process 316
- cell surface receptor signaling pathway 315
- cadherin binding 308
- DNA damage response 305
- early endosome 303
- ubiquitin protein ligase binding 302
- endosome 301
- microtubule 299
- lysosome 292
- transcription coactivator activity 291
- DNA-binding transcription repressor activity, RNA polymerase II-specific 288
- positive regulation of apoptotic process 284
- actin binding 282
- small GTPase binding 282
- neuron projection 278
- cytoplasmic vesicle 277
- actin cytoskeleton 274
- GTPase activator activity 269
- basolateral plasma membrane 267
- microtubule binding 266
- cell migration 265
- nuclear membrane 264
- sequence-specific DNA binding 262
- positive regulation of cell migration 260
- angiogenesis 257
- endosome membrane 257
- intracellular protein transport 255
- DNA repair 253
- mRNA binding 253
- protein stabilization 245
- postsynaptic density 241
- signaling receptor activity 240
- protein phosphorylation 237
- magnesium ion binding 234
- defense response to virus 233
- negative regulation of gene expression 231
- transcription by RNA polymerase II 231
- protein-macromolecule adaptor activity 229
- response to xenobiotic stimulus 229
- cilium assembly 228
- chromatin remodeling 227
- positive regulation of canonical NF-kappaB signal transduction 227
- microtubule cytoskeleton 226
- cell-cell signaling 225
- chromosome 225
- in utero embryonic development 224
- guanyl-nucleotide exchange factor activity 223
- ubiquitin-dependent protein catabolic process 222
- chemical synaptic transmission 220
- mitochondrial outer membrane 218
- regulation of cell cycle 217
- transcription corepressor activity 216
- transcription cis-regulatory region binding 214
- protein domain specific binding 211
- early endosome membrane 210
- brain development 209
- actin cytoskeleton organization 208
- transcription regulator complex 208
- visual perception 208
- heart development 207
- calmodulin binding 206
- mRNA processing 206
- receptor complex 204
- gene expression 203
- positive regulation of MAPK cascade 201
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 200
- protein kinase activity 200
- actin filament binding 199
- membrane raft 198
- nuclear envelope 197
- ubiquitin-protein transferase activity 197
- centriole 195
- regulation of gene expression 195
- regulation of apoptotic process 192
- adherens junction 190
- lamellipodium 190
- midbody 189
- positive regulation of ERK1 and ERK2 cascade 189
- cytokine activity 187
- molecular adaptor activity 187
- postsynapse 186
- presynapse 185
- trans-Golgi network 185
- carbohydrate binding 184
- RNA polymerase II-specific DNA-binding transcription factor binding 184
- lipid metabolic process 183
- postsynaptic membrane 183
- RNA splicing 183
- cell junction 182
- cell-cell junction 182
- mRNA splicing, via spliceosome 181
- axon guidance 179
- serine-type endopeptidase activity 177
- histone binding 173
- vesicle-mediated transport 171
- DNA-binding transcription factor binding 169
- endocytosis 169
- heparin binding 169
- homophilic cell adhesion via plasma membrane adhesion molecules 168
- protein folding 168
- cell cortex 167
- response to hypoxia 167
- ribonucleoprotein complex 167
- cellular response to lipopolysaccharide 166
- Wnt signaling pathway 166
- neuron differentiation 165
- translation 165
- structural constituent of ribosome 164
- mitochondrial membrane 163
- structural molecule activity 162
- cell-cell adhesion 161
- fibrillar center 161
- growth factor activity 161
- cell population proliferation 159
- sensory perception of sound 159
- intracellular protein localization 158
- immunoglobulin complex 156
- late endosome 156
- protein localization to plasma membrane 155
- transmembrane signaling receptor activity 155
- acrosomal vesicle 154
- axoneme 154
- kinetochore 154
- late endosome membrane 153
- perikaryon 151
- autophagy 150
- dendritic spine 150
- lipid binding 150
- sperm flagellum 150
- vesicle 150
- adenylate cyclase-activating G protein-coupled receptor signaling pathway 149
- defense response to bacterium 149
- endomembrane system 149
- negative regulation of neuron apoptotic process 149
- protein dimerization activity 149
- sperm midpiece 149
- transmembrane transporter binding 148
- integrin binding 147
- centriolar satellite 146
- protein polyubiquitination 145
- mitotic spindle 143
- protein-containing complex assembly 143
- blood microparticle 142
- chromatin organization 142
- flagellated sperm motility 142
- negative regulation of cell migration 142
- sperm principal piece 142
- actin filament organization 141
- central nervous system development 141
- heme binding 141
- negative regulation of canonical Wnt signaling pathway 140
- spindle 140
- positive regulation of angiogenesis 139
- regulation of cell population proliferation 139
- ubiquitin-like ligase-substrate adaptor activity 139
- detection of chemical stimulus involved in sensory perception of smell 138
- positive regulation of cytosolic calcium ion concentration 138
- spindle pole 137
- synaptic vesicle membrane 137
- T cell receptor complex 137
- presynaptic membrane 136
- recycling endosome 135
- chromosome, telomeric region 134
- extracellular matrix organization 134
- microtubule cytoskeleton organization 134
- osteoblast differentiation 133
- regulation of cell shape 133
- Z disc 133
- response to lipopolysaccharide 132
- bicellular tight junction 131
- cell adhesion molecule binding 131
- growth cone 131
- histone deacetylase binding 131
- nuclear matrix 131
- skeletal system development 131
- iron ion binding 130
- spliceosomal complex 130
- cellular response to hypoxia 129
- RNA polymerase II transcription regulator complex 128
- neuron projection development 127
- protein homooligomerization 127
- cytokine-mediated signaling pathway 125
- ficolin-1-rich granule lumen 125
- phospholipid binding 125
- antigen binding 124
- hydrolase activity 124
- mitotic cell cycle 124
- regulation of protein stability 124
- cytoplasmic vesicle membrane 123
- glucose homeostasis 123
- unfolded protein binding 123
- cytoskeleton organization 122
- nucleic acid binding 122
- phospholipase C-activating G protein-coupled receptor signaling pathway 122
- Golgi organization 121
- carbohydrate metabolic process 120
- endoplasmic reticulum to Golgi vesicle-mediated transport 120
- neuron migration 120
- anatomical structure morphogenesis 119
- kidney development 119
- potassium ion transmembrane transport 119
- receptor ligand activity 119
- response to oxidative stress 119
- G protein activity 118
- negative regulation of inflammatory response 118
- multicellular organism growth 117
- rRNA processing 117
- secretory granule lumen 117
- synaptic vesicle 117
- transcription coregulator activity 117
- chemotaxis 116
- postsynaptic density membrane 116
- response to virus 116
- T cell receptor signaling pathway 116
- Notch signaling pathway 115
- positive regulation of neuron projection development 115
- regulation of small GTPase mediated signal transduction 115
- xenobiotic metabolic process 115
- negative regulation of cell growth 114
- protein import into nucleus 114
- SH3 domain binding 114
- defense response to Gram-positive bacterium 113
- keratin filament 113
- spermatid development 113
- cytoplasmic side of plasma membrane 112
- exocytosis 112
- GABA-ergic synapse 112
- odorant binding 111
- peroxisome 111
- positive regulation of inflammatory response 111
- recycling endosome membrane 111
- trans-Golgi network membrane 111
- intracellular calcium ion homeostasis 110
- positive regulation of tumor necrosis factor production 110
- response to bacterium 110
- response to ethanol 110
- metalloendopeptidase activity 109
- mitochondrion organization 109
- beta-catenin binding 108
- positive regulation of canonical Wnt signaling pathway 108
- protease binding 108
- protein autophosphorylation 108
- sensory perception of smell 108
- ubiquitin ligase complex 108
- Golgi lumen 107
- lipid droplet 107
- MAPK cascade 107
- monoatomic ion transport 107
- canonical Wnt signaling pathway 106
- cell morphogenesis 106
- PML body 106
- side of membrane 106
- cell-matrix adhesion 105
- cysteine-type deubiquitinase activity 105
- hormone activity 105
- regulation of actin cytoskeleton organization 105
- regulation of cell migration 105
- structural constituent of cytoskeleton 105
- double-strand break repair via homologous recombination 104
- male gonad development 104
- cellular response to leukemia inhibitory factor 103
- methylation 103
- ruffle 103
- sarcolemma 103
- transforming growth factor beta receptor signaling pathway 103
- cellular response to oxidative stress 102
- integrin-mediated signaling pathway 102
- intermediate filament 102
- serine-type endopeptidase inhibitor activity 102
- single-stranded DNA binding 102
- axonogenesis 101
- establishment of localization in cell 101
- melanosome 101
- nucleosome 101
- phosphatidylinositol binding 101
- positive regulation of cold-induced thermogenesis 101
- positive regulation of JNK cascade 101
- protein-folding chaperone binding 101
- site of double-strand break 101
- transmembrane transport 101
- cholesterol homeostasis 100
- P-body 100
- Schaffer collateral - CA1 synapse 100
- ubiquitin binding 100
- positive regulation of interleukin-6 production 99
- protein maturation 99
- DNA replication 98
- intercellular bridge 98
- kinase binding 98
- lysosomal lumen 98
- muscle organ development 98
- response to endoplasmic reticulum stress 98
- secretory granule membrane 98
- cellular response to insulin stimulus 97
- cellular response to tumor necrosis factor 97
- cytoplasmic stress granule 97
- negative regulation of angiogenesis 97
- protein K48-linked ubiquitination 97
- regulation of inflammatory response 97
- ruffle membrane 97
- chromosome segregation 95
- double-stranded DNA binding 95
- protein deubiquitination 95
- epithelial cell differentiation 94
- mitochondrial translation 94
- mRNA 3'-UTR binding 94
- neuropeptide signaling pathway 94
- transport vesicle 94
- blood coagulation 93
- ERAD pathway 93
- negative regulation of canonical NF-kappaB signal transduction 93
- protein tyrosine kinase activity 93
- anterior/posterior pattern specification 92
- cell surface receptor protein tyrosine kinase signaling pathway 92
- fat cell differentiation 92
- negative regulation of transforming growth factor beta receptor signaling pathway 92
- protein processing 92
- basement membrane 91
- cytoplasmic translation 91
- cytosolic ribosome 91
- motile cilium 91
- neuron apoptotic process 91
- small GTPase-mediated signal transduction 91
- smoothened signaling pathway 91
- specific granule membrane 91
- azurophil granule lumen 90
- nucleosome assembly 90
- protein phosphatase binding 90
- animal organ morphogenesis 89
- ATPase binding 89
- catalytic step 2 spliceosome 89
- defense response to Gram-negative bacterium 89
- memory 89
- mitochondrial intermembrane space 89
- protein tyrosine phosphatase activity 89
- calcium ion transport 88
- Golgi cisterna membrane 88
- immunoglobulin mediated immune response 88
- locomotory behavior 88
- secretory granule 88
- single fertilization 88
- calcium-mediated signaling 87
- modulation of chemical synaptic transmission 87
- peptidase activity 87
- antimicrobial humoral immune response mediated by antimicrobial peptide 86
- cell chemotaxis 86
- chromatin DNA binding 86
- fatty acid metabolic process 86
- positive regulation of cell growth 86
- neural tube closure 85
- nuclear pore 85
- phosphatidylinositol-4,5-bisphosphate binding 85
- retrograde transport, endosome to Golgi 85
- transport across blood-brain barrier 85
- BMP signaling pathway 84
- cell projection 84
- PDZ domain binding 84
- amyloid-beta binding 83
- cellular response to starvation 82
- G1/S transition of mitotic cell cycle 82
- lung development 82
- monoatomic ion transmembrane transport 82
- neuromuscular junction 82
- oxidoreductase activity 82
- potassium ion transport 82
- transmembrane transporter activity 82
- calcium-dependent protein binding 81
- endoplasmic reticulum-Golgi intermediate compartment membrane 81
- neurogenesis 81
- positive regulation of neuron differentiation 81
- positive regulation of protein catabolic process 81
- stress fiber 81
- voltage-gated potassium channel complex 81
- cytoplasmic ribonucleoprotein granule 80
- double-strand break repair 80
- protein serine/threonine phosphatase activity 80
- regulation of protein localization 80
- signaling adaptor activity 80
- synapse assembly 80
- tRNA binding 80
- virus receptor activity 80
- autophagosome 79
- cellular response to virus 79
- epidermis development 79
- liver development 79
- muscle contraction 79
- negative regulation of translation 79
- positive regulation of autophagy 79
- post-embryonic development 79
- actin filament 78
- calcium ion transmembrane transport 78
- cellular response to calcium ion 78
- cholesterol metabolic process 78
- extracellular matrix structural constituent 78
- GDP binding 78
- positive regulation of NF-kappaB transcription factor activity 78
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process 78
- Ras protein signal transduction 78
- response to estradiol 78
- cerebral cortex development 77
- endoplasmic reticulum-Golgi intermediate compartment 77
- enzyme activator activity 77
- filopodium 77
- microtubule organizing center 77
- phagocytic vesicle membrane 77
- phosphatidylinositol 3-kinase/protein kinase B signal transduction 77
- positive regulation of protein ubiquitination 77
- regulation of RNA splicing 77
- serine-type peptidase activity 77
- sodium ion transmembrane transport 77
- cellular response to mechanical stimulus 76
- cellular response to type II interferon 76
- endocytic vesicle membrane 76
- receptor-mediated endocytosis 76
- RNA processing 76
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 75
- double-stranded RNA binding 75
- B cell differentiation 74
- female pregnancy 74
- negative regulation of ERK1 and ERK2 cascade 74
- positive regulation of type II interferon production 74
- promoter-specific chromatin binding 74
- protein O-linked glycosylation 74
- regulation of cell growth 74
- response to toxic substance 74
- autophagosome assembly 73
- ribosomal small subunit biogenesis 73
- small-subunit processome 73
- tertiary granule membrane 73
- apoptotic signaling pathway 72
- cell body 72
- chloride transmembrane transport 72
- defense response 72
- insulin receptor signaling pathway 72
- positive regulation of translation 72
- regulation of translation 72
- response to insulin 72
- scaffold protein binding 72
- apical part of cell 71
- calcium channel activity 71
- collagen fibril organization 71
- DNA-templated transcription 71
- endopeptidase activity 71
- endosomal transport 71
- keratinization 71
- regulation of blood pressure 71
- response to wounding 71
- ribosome binding 71
- cellular response to retinoic acid 70
- ciliary transition zone 70
- clathrin-coated endocytic vesicle membrane 70
- intermediate filament organization 70
- macroautophagy 70
- manganese ion binding 70
- ossification 70
- p53 binding 70
- phagocytic vesicle 70
- phagocytosis 70
- positive regulation of osteoblast differentiation 70
- protein autoubiquitination 70
- protein dephosphorylation 70
- antiviral innate immune response 69
- caveola 69
- ciliary tip 69
- hematopoietic progenitor cell differentiation 69
- hippocampus development 69
- intracellular iron ion homeostasis 69
- lipid catabolic process 69
- microvillus 69
- positive regulation of endothelial cell proliferation 69
- regulation of alternative mRNA splicing, via spliceosome 69
- basal plasma membrane 68
- circadian rhythm 68
- meiotic cell cycle 68
- negative regulation of neuron projection development 68
- photoreceptor inner segment 68
- protein homotetramerization 68
- regulation of autophagy 68
- RNA helicase activity 68
- wound healing 68
- aerobic respiration 67
- cellular response to hydrogen peroxide 67
- circadian regulation of gene expression 67
- damaged DNA binding 67
- endocytic recycling 67
- platelet alpha granule lumen 67
- positive regulation of synapse assembly 67
- tubulin binding 67
- cis-Golgi network 66
- determination of left/right symmetry 66
- keratinocyte differentiation 66
- peroxisomal membrane 66
- protein catabolic process 66
- protein modification process 66
- regulation of cytokine production 66
- regulation of membrane potential 66
- rhythmic process 66
- roof of mouth development 66
- SNARE binding 66
- cartilage development 65
- endocytic vesicle 65
- lateral plasma membrane 65
- learning or memory 65
- mRNA transport 65
- negative regulation of tumor necrosis factor production 65
- neuron development 65
- photoreceptor outer segment 65
- positive regulation of epithelial cell proliferation 65
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